![]() ![]() Credit: NIH/SPL A person with HIV seems to be free of the virus after receiving a stem-cell transplant that replaced. "In particular, the results of this study are also enormously important for further research into a cure for HIV for the vast majority of people living with HIV for whom stem cell transplantation is not an option. Matthew Warren HIV (yellow) infecting a human immune cell (blue). ![]() Julian Schulze zur Wiesch, DZIF scientist at the University Medical Center Hamburg-Eppendorf and one of the study leads. PARIS A man known as the Duesseldorf patient has become the third person declared cured of HIV after receiving a stem cell transplant that also treated his leukemia, a study said on Monday. "This case of curing a chronic HIV infection by stem cell transplantation shows that HIV can in principle be cured," says Prof. in blood tests, and does not seem to have. And while this is the third known case, according to Bryson's team, of HIV remission in an individual. More than 14 months later, she now shows no signs of H.I.V. Previously, only two men have been cured of HIV using a bone marrow or stem cell transplant. Ten years after transplantation and four years after the end of anti-HIV therapy, the Düsseldorf patient could be declared cured by the international research consortium. The patient opted to discontinue antiretroviral therapy 37 months after the transplant. More than four years ago, the antiviral therapy against HIV was discontinued. Already shortly after transplantation and over the entire course of the study years, neither replicating virus nor antibodies or reactive immune cells against HIV were detected. Using a variety of sensitive techniques, the researchers analysed the patient's blood and tissue samples to closely monitor immune responses to HIV and the continued presence or even replication of the virus. This mutation makes it impossible for most HI viruses to enter human CD4+ T-lymphocytes, their major target cells.įollowing transplantation, the patient was carefully monitored virologically and immunologically for almost ten years. A woman has gone 14 months without detectable levels of HIV in her body following an experimental stem cell transplant procedure. As in the cases of the first two patients named "Berlin" and "London," the Düsseldorf patient received stem cells from a healthy donor whose genome contains a mutation in the gene for the HIV-1 co-receptor CCR5. ![]() The patient, treated at the University Hospital Düsseldorf for his HIV infection, had received a stem cell transplant due to a blood cancer. published 16 March 2023 A woman who received a stem cell transplant to treat her HIV is still virus-free more than five years after the procedure and 30 months after she stopped. The "Düsseldorf patient," a 53-year-old man, is now the third person in the world to be completely cured of the HI virus by a stem cell transplant. The reason for this is that the virus "sleeps" in the genome of infected cells for long periods of time, making it invisible and inaccessible to both the immune system and antiviral drugs. The cells are collected after the birth of a baby before the umbilical cord and placenta are disposed of, it said.An infection with the human immunodeficiency virus (HIV) was previously considered incurable. The blood that flows through the placenta and umbilical cord has a high concentration of stem cells, which is what is sourced through bone marrow transplants, according to Johns Hopkins research. Scientists believe these individuals then develop an immune system resistant to HIV. Patients in the trial first undergo chemotherapy to kill off the cancerous immune cells.ĭoctors then transplant stem cells from individuals with a specific genetic mutation in which they lack receptors used by the virus to infect cells. There are three sources of stem cells used in transplants: bone marrow, surrounding blood stem cells, or, the newest approach, from umbilical cords. It aims to follow 25 people with HIV who undergo a transplant with stem cells taken from umbilical cord blood for the treatment of cancer and other serious conditions.Ī stem cell transplant is done by transferring stem cells from one person to another. The case is part of a larger US-backed study led by Dr Yvonne Bryson of the University of California Los Angeles (UCLA), and Dr Deborah Persaud of Johns Hopkins University in Baltimore. MONTREAL A 66-year-old US man has become the worlds fourth known HIV patient to show complete clearance of the virus after being treated for acute myelogenous leukemia with an allogeneic. ![]()
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